Ins and outs of Ca2+ transport by acidic organelles and cell migration
نویسنده
چکیده
ARTICLE HISTORY Received 8 May 2017 Accepted 15 May 2017 ABSTRACT Much contemporary evidence underscores the pathophysiological importance of Ca2C handling by acidic organelles such as lysosomes. Whereas our knowledge of how Ca2C is released from these acidic Ca2C stores (the ‘outs’) is advancing, we know relatively little about how Ca2C uptake is effected (the ‘ins’). Here I highlight new work identifying animal Ca2C/HC (CAX) exchangers that localize to acidic organelles, mediate Ca2C uptake and regulate cell migration in vivo. Continued molecular definition of the acidic Ca2C store toolkit provides new insight into Ca2C-dependent function.
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